Proton-coupled folate transporter pcft

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August undefined, 2024

WebbPCFT is involved in the process of using energy to move certain B vitamins called folates across the brush border membrane for absorption, a mechanism called active transport. … Webb6 mars 2007 · This article reviews (1) the characteristics and prevalence of the low-pH folate transport activity, (2) its relationship to, and properties of, the recently identified …

(PDF) The human proton-coupled folate transporter - ResearchGate

WebbThe proton-coupled folate transporter (PCFT) plays a key role in intestinal folate absorption, and loss-of-function mutations in the gene encoding this transporter are the … Webb先天性葉酸吸収不全症は葉酸の輸送体であるproton-coupled folate transporter (PCFT)の機能喪失を原因とする常染色体劣性遺伝性疾患である。腸管からの葉酸吸収不全と脈絡膜における取り込み障害により, 乳児期早期から巨赤芽球性貧血, 免疫不全, 遷延性下痢, 精神発達遅滞, 痙攣などをきたす。大脳基底核に石灰化病変を認めることがある。 2．原因 … flat mounted speakers

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Webb2 feb. 2009 · Recently, this laboratory identified a proton-coupled folate transporter (PCFT), with optimal activity at low pH. PCFT is critical to intestinal folate absorption … Webb1 apr. 2024 · Elevated serum folate levels, like those seen in our patients, could also reflect changes in transport of folate in and out of cells. There are three main types of folate transporters: reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptors. Folate receptors have four isoforms: FRα, FRβ, FRγ, and FRδ [51 ... Webb18 dec. 2024 · The proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid … check power at headlights

Functional roles of aspartate residues of the proton-coupled folate …

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Webb9 dec. 2010 · The proton-coupled folate transporter (PCFT; SLC46A1) mediates folate transport into enterocytes in the proximal small intestine; pcft loss-of-function mutations … Webb18 mars 2024 · There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled … check powerball numbers moWebbThe proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid plexus4,7, and is an … check powerball numbers missouri

"Webb18 nov. 2024 · The Proton-Coupled Folate Transporter (PCFT) is a transmembrane transport protein that controls the absorption of dietary folates in the small intestine. … " - Proton-coupled folate transporter pcft

Proton-coupled folate transporter pcft

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WebbRecent studies have identified the proton-coupled folate transporter (PCFT) as the mechanism by which folates are absorbed across the apical brush-border membrane of … WebbIt is considered that our methodology is useful to Proton-coupled folate transporter (PCFT) and elucidate concentration patterns of transporter Multidrug resistance …

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Webb1 feb. 2010 · The human proton-coupled folate transporter ... To evaluate vectorial transport, MDCKII-PCFT, and MDCK vector control cells were seeded at a density of 5 × … Webb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

Webb6 juni 2024 · The proton-coupled folate transporter (PCFT) is a member (SLC46A1) of the superfamily of solute transporters. The major physiological roles of PCFT are in … Webb8 apr. 2024 · Elevated serum folate levels, like those seen in our patients, could also reflect changes in transport of folate in and out of cells. There are three main types of folate transporters: reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptors. Folate receptors have four isoforms: FRα, FRβ, FRγ, and FRδ

WebbHowever, there were discrepancies between the properties of these transporters and characteristics of folate transport in many tissues, most notably the intestinal … Webb26 maj 2024 · The proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid …

Webb6 sep. 2012 · This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT was identified in 2006 as the primary transporter for intestinal absorption …

WebbFolates are essential for nucleic acid synthesis and are particularly required in rapidly proliferating tissues, such as intestinal epithelium and hemopoietic cells. Availability of dietary folates is determined by their absorption across the intestinal epithelium, … flat mounted tremoloWebbFor methotrexate and PT523, uptake by RFC predominated even in the presence of PCFT or FRα. For both classic (methotrexate, PT523) and FRα-targeted (AGF102) antifolates, anti … flat mounted wooden eagleWebbThe proton-coupled folate transporter (PCFT), a member (SLC46A1) of the superfamily of solute transporters, harnesses the proton gradient as the energy source to achieve uphill … check powerball numbers nyWebb21 mars 2024 · Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17129779, 17446347, 17475902, 19389703, … check powerball numbers onlineWebb1 dec. 2001 · Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge … check powerball numbers ncWebbHere, entry is assumed to be primarily governed by the reduced folate carrier (RFC1, gene name: SLC19A1), and the proton-coupled folate transporter (PCFT, gene name: … check powerball numbers texasWebbFolate is essential for DNA synthesis, repair and methylation. The uptake into cells is mediated by three transport mechanisms: The main transport is via the reduced folate carrier (RFC), followed by the proton-coupled folate … flat mount facing tool