WebDec 1, 2024 · Wen Zhang 1 , Yao Wang 1 , Chuanwei Li 2 , Yu Xu 1 , Xia Wang 1 , Di Wu 1 , Zhan Gao 1 , Hang Qian 1 ... Moreover, EPO treatment hardly promotes M2 polarization in Rab26 knockout (KO) macrophages through EPOR. Collectively, macrophage EPOR signaling is impaired by eCIRP through Rab26 during ALI/ARDS, leading to the … WebRNA-seq analyses of the newly identified EBI macrophages revealed that EBI macrophages have involved specialized function in supporting erythropoiesis. Our findings …
Identification and Functional Analysis of EPOR + Tumor …
WebThe identity of EBI macrophages has thus far remained elusive. Given that Epo is essential for erythropoiesis and that Epor is expressed in numerous nonerythroid cells, we hypothesized that EBI macrophages express Epor so that Epo can act on both erythroid cells and EBI macrophages simultaneously to ensure efficient erythropoiesis. Webonstrated that EPOR is expressed in nonerythroid cells, such as the brain, kidneys, heart, and various tumor cell lines [20– 24]. Specifically, it has been reported that EPOR can … ohenry writings
Identification and Functional Analysis of EPOR + Tumor …
WebAug 1, 2024 · RNA-seq analyses of BM F4/80 + Epor-eGFP + and F4/80 + Epor-eGFP-macrophages. (A) Principal component analysis. (B) Heatmap of the differentially … WebAug 1, 2024 · Abstract. In this issue of Blood, Li et al show that erythropoietin receptor (Epor) expression marks the central macrophage of the erythroblastic island (EBI). Treatment with Epo increases the number of EBIs as well as the number of erythroblasts surrounding the central macrophage. WebOct 28, 2024 · Tissue-resident macrophages can be educated to tumor-associated macrophages (TAMs) by the tumor microenvironment and many types of macrophages … ohenry writing desk