Cumulative weighted context++ score
WebAug 24, 2024 · Cumulative weighted context++ score：累计加权分值，数字越小，靶点可能性越大； Total context++ score：总评分值，数字越小，靶点可能性越大； Aggregate PCT：种间进化保守计算的分值，分值越高，保守性越广； Previous TargetScan publication (s)：报道该靶点预测的参考文献。 三、点击Sites in UTR（结合位点） 以miRNA的靶基 … WebAs an option, predictions are also ranked on the basis of targeting efficacy estimated using cumulative weighted context++ scores of the sites (Agarwal et al., 2015). As another …
Cumulative weighted context++ score
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WebMay 14, 2024 · The hypothetical targets could be predicted for 172 miRNAs. 438 genes were predicted to be the targets with high confidence (cumulative weighted context … WebThe context++ score (CS) for a specific site is the sum of the contribution of 14 features. A weighted context++ score (WCS; Nam et al., 2014) adds the contribution of the …
WebSep 1, 2024 · Cumulative weighted context++ score: This score estimates the total repression expected from multiple sites of the same miRNA, for each mRNA target predicted. 1.1. Cancer stem cells and Wnt pathway. WNT signaling is implicated in various key processes such self-renewal of cancer stem cells and differentiation via several … WebTo calculate the cumulative weighted context++ score (CWCS; Agarwal et al., 2015 ), for each site i, from 1 to n, the cumulative predicted repression at that site (C i) was …
WebDec 1, 2024 · 1. Introduction. Extracellular matrix is a dynamic meshwork of macromolecules that plays an important role in biological processes such as tissue remodeling (Page-McCaw et al., 2007) and various developmental processes like tooth and skeletal development (Fukumoto and Yamada, 2005), neural crest migration, maturation … WebNov 14, 2024 · Predictions with Cumulative weighted context++ score < −0.4 in TargetScanHuman were selected, as well as those with a miTG-score > 0.7 in LncBase Predicted v.2. The ceRNA network was visualized by using Cytoscape.
WebSep 17, 2024 · (A) The predicted pairing between target human 3′-untranslated regions of mRNA sequences (top, underlined) and human microRNA (miRNA) sequences (bottom, underlined) and the cumulative weighted context++ scores (right column), which indicate target effectiveness according to in silico screening (targetscan.org).
WebMar 20, 2024 · A cumulative weighted context++ score online >-0.5 was set as the standard for screening target genes, as previously described . The target genes were then uploaded to the online database Search Tool for the Retrieval of Interacting Genes and Proteins (STRING; string-db.org) to obtain the interaction information for these target … granite farmington ctWebApr 15, 2024 · Glycogen synthase 1 (GYS1) was identified in both programs as a target with high score for miR-122 in human (target score 95, miRDB) and bovine (-0.96 cumulative weighted context++ score; TargetScan8.0). Additional predicted targets for miR-122 included forkhead box O3 (FOXO3) and myocyte enhancer factor 2D (MEF2D). granite farmhouse kitchen sinksWebTo calculate the CWCS, for each site i, from 1 to n, the cumulative predicted repression at that site (C i) was calculated as C i = C (i-1) + (1-2 CSi ) (AIR i -C (i-1) ), in which CS i … chin mount standard gopro helmetWebMay 9, 2024 · The interaction score of not < 0.7 (high confidence score) was considered significant and the PPI was visualized. ... According to the predicted efficacy of targeting … granite fantasy brown polishedWebFeb 23, 2024 · Target genes were checked for following parameters: (i) their representative transcripts, (ii) number of 3P-seq tags supporting UTR +5, (iii) link to sites in UTRs, (iv) conserved sites/poorly conserved sites, (v) cumulative weighted context++ score, (vi) total context++ score, and (vii) aggregate PCT (preferentially conserved targeting) values. granite farmhouse sinkWebComparing the sum of the predicted site scores in coding sequence (CDS score) against various 3'UTR sizes of targeted (green line) and non-targeted (blue line) genes on an independent test set ... chin mouthWebIn mammals, predictions are ranked based on the predicted efficacy of targeting as calculated using cumulative weighted context++ scores of the sites ( Agarwal et al., 2015 ). As an option, predictions are also ranked by their probability of conserved targeting ( P CT, Friedman et al., 2009 ). granite falls ww2 museum