WebOct 21, 2024 · In a novel research of Cai's group, they found that circBACH2 was a tumor promoter in PTC, which modulated miR-139-5p as a sponge, thereby regulating the downstream gene LMO4 to suppress proliferation, migration, and invasion . Liu and colleagues observed that levels of circRAPGEF5 are higher in PTC than in adjacent … WebMoreover, the circBACH2 (hsa_circ_0001625) was confirmed to act as hsa-miR-944 sponge to stimulate HNRNPC expression to promote BC cell proliferation via MAPK signaling pathway, thus constructing a circBACH2/hsa-miR-944/HNRNPC axis in BC. Conclusions Our findings decipher a novel circRNA-based m6A regulatory mechanism …
Up-regulated circBACH2 contributes to cell proliferation, invasion, …
http://circrna.org/ WebMar 24, 2024 · Molecular quantitative trait locus (QTL) mapping of genetic variants with intermediate molecular phenotypes has proven to be a powerful approach for prioritizing genetic regulatory variants and causal genes identified by Genome-wide association studies (GWAS). Recently, this success has been extended to circular RNA (circRNA), a … shanta kumar committee report on msp
Circular RNA circBACH2 plays a role in papillary thyroid …
Websome potential binding sites on circBACH2, and this circRNA functioned by sponging miR‑139‑5p. RT‑qPCR, western blot analysis and CCK‑8 assay revealed that circBACH2 sponged miR‑139‑5p and suppressed its inhibitory effect on LIM domain only 4 (LMO4) (40). These results indicate that circBACH2 mediates PTC cell progression and ... WebClinical and Translational Oncology 1 3 early screening, precise diagnosis and prognosis monitoring of diseases, which have important theoretical and application WebcircBACH2 LMO4 Up miR-139-5p Suppress proliferation, migration, and invasion A promising prognostic biomarker and potential treatment strategy for PTC circBACH2/miR-139-5p/LMO4 axis [45] circRAPGEF5 RAPGEF5 Up miR-198 Bene fi cial to proliferation, migration, and invasion in vitro A potential biomarker and therapeutic target for the … shantal anderson