Chloramphenicol excretion
WebTotal urinary excretion of chloramphenicol in these studies ranged from a low of 68% to a high of 99% over a three-day period. From 8% to 12% of the antibiotic excreted is in the form of free chloramphenicol; the remainder consists of microbiologically inactive metabolites, principally the conjugate with glucuronic acid. WebBIOLOGICAL DATA Biochemical aspects Absorption, distribution, and excretion In dogs, chloramphenicol is rapidly and extensively absorbed after oral administration of 50 mg/kg b.w., giving plasma levels of 16.5 g/l 2 hours after …
Chloramphenicol excretion
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Web6.1 Absorption, distribution, metabolism, and excretion ..... 29 6.2 Toxicity ... Chloramphenicol was isolated from Streptomyces venezuelae in 1947. Chloramphenicol was found to be effective against typhus in 1948 and became the first antibiotic to
WebChloramphenicol is rapidly absorbed, metabolized and excreted. In man the major route of excretion is by way of the kidneys, with approximately 90 per cent of the administered … WebPatients with renal insufficiency may exhibit prolonged half-life, since chloramphenicol is cleared by renal excretion. Chloramphenicol, while an effective antibiotic, must be …
WebDec 1, 1979 · We studied the pharmacokinetics of chloramphenicol following its intravenous administration as the sodium succinate ester to 54 infants and children. The mean “apparent t1//2” of chloramphenicol clearance from the plasma was 5.94 hours (range 0.87 to 17.8 hours). The t1/2 of patients who weighed less than 10 kg was … WebFeb 17, 2024 · One study reported 50 breastfed infants whose mothers were give oral chloramphenicol beginning 2 to 12 days postpartum in dosages of 1 (n = 20), 2 (n = …
WebJul 4, 2024 · Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa. ... by …
WebChloramphenicol is rapidly absorbed, metabolized and excreted. In man the major route of excretion is by way of the kidneys, with approximately 90 per cent of the administered dose accounted for in 24 hours. Lesser amounts are excreted in the urine of lower animals. The bulk of the excreted drug is in the form of an inactive nitro compound, and less than 10 … braci barùWebApr 4, 2024 · Chloramphenicol is rapidly absorbed after oral administration. In the liver, chloramphenicol is inactivated by conjugation with glucuronic acid or by reduction to inactive aryl amines. Excretion is mainly renal, though some bile excretion occurs following oral administration. 5.3 Preclinical Safety Data. Genotoxicity. No data available ... bracikiWebDec 10, 2024 · Chloramphenicol is excreted mainly in the urine but only 5 to 10% of an oral dose appears unchanged; the remainder is inactivated in the liver, mostly by conjugation with glucorinic acid. ... metabolism, and excretion of chloramphenicol are subject to considerable interindividual variation, especially in infants and children, making … braci e graniWebFor a given sample, total nitro content minus chloramphenicol content indicates metabolite content. The data for chloramphenicol glucuronide, the major metabolite, indicate a … bracikaWebExcretion of chloramphenicol in human milk. Excretion of chloramphenicol in human milk. Excretion of chloramphenicol in human milk Chemotherapia (Basel). … bracikWebInactivation occurs primarily by hepatic glucuronidation. Hepatic insufficiency is known to decrease metabolism but rarely requires dose modification. Chloramphenicol has an … braci krausseWebThe area under the serum concentration vs time curve of chloramphenicol and urinary excretion of chloramphenicol succinate were determined in each child under steady-state conditions while receiving chloramphenicol succinate and again while receiving chloramphenicol palmitate. The mean AUC was significantly greater during oral therapy … braci e grani milano