WebOct 1, 2011 · For scale-up, we cultured cells in a traditional stainless-steel 120-L bioreactor with 100-L working volume or in a WAVE Bioreactor system 200 with a working volume of 100 L. ... we performed a virus inactivation treatment for 40 min at pH 3.8. Between the virus inactivation and the polishing step, ... BioPharm Int. 19:48-53. 4.) Shukla, AA ... WebpH is a critical parameter in development and scale-up of cell culture and microbial bioprocesses, as well as in most downstream applications. Bioreactors, even the smallest, are equipped with pH sensors for process control, but often deviations between in-line and offline sample measurements can reach up to a whole pH unit, creating ...
Downstream Processing in Biopharma - Mettler Toledo
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Biopharm Inc. - Quality Assurance & Traceability
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